Difference between revisions of "Brain hackers"

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This is the page of the '''Brain Hackers''' aka the Neurohacking/Neuromodulation London Hackspace Group. We do experiments and play around with kits to measure and alter brain activity in a non-invasive way and develop novel accessible neurostimulation means accompanied by real time measurement and feedback. Some of us are trained neuroscientists or electronics engineers, others are hobbyists. All friendly and interested people are welcome to volunteer and participate in trials, but everything is obviously at your own risk (where such risk may exist).
 
This is the page of the '''Brain Hackers''' aka the Neurohacking/Neuromodulation London Hackspace Group. We do experiments and play around with kits to measure and alter brain activity in a non-invasive way and develop novel accessible neurostimulation means accompanied by real time measurement and feedback. Some of us are trained neuroscientists or electronics engineers, others are hobbyists. All friendly and interested people are welcome to volunteer and participate in trials, but everything is obviously at your own risk (where such risk may exist).
  
We are now in the process of organizing and starting work on a few specific projects from the project ideas listed below. More update on this in the coming weeks.
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'''DIY news:'''
  
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- the current ICIBCI meeting is https://www.meetup.com/NeuroTechLDN/events/245406475/# The page for the project is https://icibici.github.io/site/ and Git is at https://github.com/icibici/Android-diagnostic-app It works, and if anyone wants a kit to try, improve, and develop apps, please contact Colin Rowat <c.rowat@espero.org.uk>
  
'''''List of kit available by different members of the group:'''''
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- There is a first academic review of ICIBCI at http://robertoostenveld.nl/first-steps-with-a-e20-single-channel-eeg-system/
  
 +
- Starting to use pink noise bands for both brainwave entrainment and covering cyclotron/larmor spectra of relevant ions using weak (a few dozen of microtesla) magnetic fields and modulated HF at 24 MHz. Emulation of global geomagnetic resonators ULF bands is to follow.
  
-EEG -> multiple copies of the 1 channel bipolar (TrueSense Kit) recorder, multiple copiMindWave Mobile (1 channel), Emotiv Epoc (14 channels), KT88 (16 channels, photoic stimulation), AMEA slow potentials mapper (2 channels), new model of AMEA expected Feb
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- It appears, that brainwave entrainment using weak (up to 30 mT) magnetic fields at 10 Hz only works well if supplemented with transcranial IR light (100 mW) at the same frequency
  
 +
- Electrophoresis of 20 % solution of Piracetam: subjective effect appears in 10-15 min, while for the traditional Piracetam intake it typically takes 1-2 weeks, and is accompanied by a remarkable elevation of higher beta and gamma activity across the whole brain as measured with Muse
  
-tDCS (transcranial direct current stimulation) -> DIY, foc.us (developers edition not arrived yet)
 
  
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'''We are now in the process of organizing and starting work on a few specific projects from the [[Brain_hackers/Project_ideas|Project Ideas]]. More update on this in the coming weeks.'''
  
-tACS (transcranial alternate current stimulation) -> DIY, DrTES (transcranial analgesia device)
 
  
 +
'''''List of measurement and stimulation kit available by different members of the group:'''''
  
-Transcranial laser / decoherent light stimulation within optical permeability window of tissues (roughly between 600 and 1200 nm) -> Matrix LLLT with in-built photometer and external SRT block, impulse modulated 890 nm and 635 nm single and matrix lasers, continuous modulated 810 and 640 nm, all-inclusive large laser/LED head, continuous red/infrared LED matrix
 
  
 +
-EEG -> multiple copies of the 1 channel bipolar (TrueSense Kit) sensor, multiple copies of MindWave Mobile (1 channel) and Muse (4 channels), Emotiv Epoc+ (14 channels), KT88 (16 channels, photic stimulation), AMEA slow potentials mapper (2 channels). We have also made an EEG sensor for an audio jack of any smartphone at IMFcamp hackathon - see above. 
  
-Weak field TMS (transcranial magnetic stimulation, microtesla range or even lower) -> 64 coil Koren helmet augmented for placement of more coils, smaller phone tap coils - based hats and setups, large (3m) coil, MIT-MT stimulator (0.1-99 Hz range) with different size coils (induction going up to 25 mT max, 8-shaped configuration up to 10 mT) including coils with centrally positioned high power red, infrared and blue LEDs for combined ligfht and magnetic stimulation
 
  
 +
-tDCS (transcranial direct current stimulation) -> DIY, via Starstim, via foc.us etc.
  
-Other -> SGR sensor, photopletismograph, modulated high voltage "singing arc", scopes, magnetometers, function generators, amps etc.
 
  
 +
-tACS/tPCS (transcranial alternate current stimulation) -> DIY, foc.us, thync, Rhythm-2 2 channel tPCS stimulation device, DrTES (transcranial analgesia device)
  
[[Brain_hackers/Project_ideas]]
 
  
'''''Some of the project ideas we are interested in and would be eager to test in regard to different neuromodulation means:'''''
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-Transcranial laser / decoherent light stimulation within optical permeability window of tissues (roughly between 600 and 1200 nm) -> Matrix LLLT with in-built photometer and external biofeedback block, impulse modulated (0-3 kHz) 890 nm and 635 nm single and matrix array lasers, continuous modulated 810 and 640 nm, all-inclusive large laser/LED combining head, Dune lamp (an array of LEDs at 632,7 and 840 nm, 3 mW)
  
  
1. tDCS
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-High Power TMS (very short pulses up to 1 Tesla, modulation 2-2500 Hz) - TDHP40DEL with 4 coils.
  
- measurement! Can it be run with simultaneous measurement of EEG activity without damaging the sensor and producing meaningful data? Currently available tDCS kits provide no real time feedback
 
  
- interaction of tDCS with other neurostimulation means including light and low induction TMS
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-Weak field TMS (transcranial magnetic stimulation, microtesla range or even lower) -> 64 coil Koren/Murphy/Persinger helmet augmented for placement of more coils, smaller phone tap coils - based hats and setups, large (3m) coil, ELF emmit coil, MIT-MT stimulators (0.1-99 Hz range) with different size coils (induction going up to 30 mT max, 8-shaped configuration up to 10 mT) including coils with centrally positioned high power red, IR and blue LEDs for combined transcranial light/photic and magnetic stimulation, MIT-11 stimulator with coils similar to MIT-MT but different induction and frequency step settings, Almag-02 Version 2 running field (up to 50 mT) pre-programmed multi-coil stimulator, Gefest peripheral feedback 4-coil stimulator (tissues impedance - modulated very low (> 1 Hz) frequency fields up to 10 mT), Biomedis M (with a 3 V jack for coils)
  
- interaction of tDCS with nootropics (such as ampakines like piracetam) or ergotropics (such as modafinil and bromantane) for those already using such drugs
 
  
 +
- SHF/THF - Aquaton weak (microwatt range) SHF stimulator (1.001 GHz that can be modulated at 0.1, 8 and 16 Hz) with an external antenna, Orbita weak (microwatt range) THF stimulators (unmodulated, 127 GHz (O2 absorbtion frequency) and 150 GHz (NO absorption frequency)), modulated 53.5 GHz module for MIT (~1 mW, 0-99 Hz range), Yav-1M (42.22 GHz, 10 mW) with signal reflection feedback via it's Gunn diode.
  
2. tACS/tRNS (transcranial random noise stimulation)
 
  
- can the benefits of both tDCS and tACS be gained if monophasic pulsed current is used?
+
- Ultrasound: MIT-11 stimulator supports 44 kHz 2-5 mkm amplitude ultrasound which can be modulated from 0 to 99.9 Hz with a 0.1 Hz step. MIT-MT emitter, 880 kHz, 1 W/cm2, modulation 0-99 Hz.
  
- the colours of noise in tRNS ! Would they make any difference?
 
  
 +
-Other -> photopletismographs with vegetative status estimation capability, modulated high voltage "singing arc", scopes, magnetometers, function generators, amps, shielded random number generator etc.
  
3. Coherent/decoherent light
+
Special thanks to: http://www.medintex.com/ for supplying us with kit to test.
  
- does the wavelength makes much difference and what is it?
+
Miscellanea:
  
- continuous light stimulation versus impulse stimulation with high peak power very short bursts: how would the effects differ?
+
Michael Persinger's "God Helmet" effectiveness has been reproduced by an independent group: http://www.scribd.com/doc/267811996/God-Helmet-Replication-Study
 
- continuous versus modulated stimulation: how do we modulate? what are the observed differences?
 
 
 
 
 
4. Weak field TMS (also called LiTMS - low induction TMS in some sources)
 
  
- do God Helmet, "octopus", "shakti" and other Dr. Persinger's stimulation protocols actually work?
+
Possible step towards CEMI: http://www.sciencedaily.com/releases/2016/01/160114121806.htm
  
- what other signals can be applied, and how
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Effects of ~100 nT 2 kHz field on short term memory and attention have been detected: http://onlinelibrary.wiley.com/doi/10.1002/bem.21944/full
  
- reproducing "Zhadin effect" (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614765/ as a starting reading material) at Hackspace - can we do it?
 
  
- generally, checking whether the KT (Bolzmann constant x temperature) thermodynamic limitation for biologic effects of weak magnetic fields withstands! (http://biomag.zz.mu/pdf/2007.Binhi.ea.EBM.pdf is a good challenge starter!)
+
Politics:
  
 +
Some of us actively stand for excluding nootropics, ergotropics and adaptogenes from this Bill together with the rest of http://www.transhumanistparty.org.uk/ - 
 +
see https://www.newscientist.com/article/2074813-youre-not-hallucinating-mps-really-did-pass-crazy-bad-drug-law/ for more details on the issue.
  
5. Other
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First they ban enhancing substances, and then go after the devices! Join the campaign if you are not indifferent.
 
 
- record and replay! Can a specific state-associated EEG recording from a selected area induce or promote this state if replayed back to the same area of the same or different person as electric or magnetic signal?
 
 
 
- producing software capable of using ERP's (Evoked Response Potentials) with simple and cheap BCI like the Mindwave or TSK sensors
 
  
  
Line 76: Line 68:
  
  
P.S.: folks from Mind Hacking and Biohacking groups are, of course, welcome to join in, but we surely need electronic engineering and coding enthusiasts interested in such matters!
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P.S.: folks from Mind Hacking and Biohacking groups are, of course, welcome to join in, but we surely need electronics and coding enthusiasts interested in such matters!
  
 
----
 
----
  
For neuroscientific and technical questions and curiosities involving brain hacking, feel free to get in touch with any of the following:
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For neuroscience and technical questions and curiosities involving brain hacking, feel free to get in touch with any of the following:
  
 
Martin Dinov
 
Martin Dinov
Line 99: Line 91:
  
 
https://wiki.london.hackspace.org.uk/w/index.php?title=File:Self_hacking_via_replay_attacks.pdf
 
https://wiki.london.hackspace.org.uk/w/index.php?title=File:Self_hacking_via_replay_attacks.pdf
 
== Bibliography ==
 
  
Some relevant reading for those who want to go hardcore :-)
+
https://wiki.london.hackspace.org.uk/w/images/b/b9/The_rise_of_neurosocial_networks.pdf
Of course it is far from being complete and needs to be updated, oh well...
 
 
  
 +
Some of us on BBC Radio 4 and on Sky TV:
  
----
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http://www.bbc.co.uk/radio/player/b050zpwt
  
 +
http://news.sky.com/story/1522367/brain-hacking-on-rise-could-it-make-you-perkier
  
* '''Accessible measurement methodologies and BCI'''
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Us at the first UK Brain hackathon as team Neurocraft:
  
 +
http://motherboard.vice.com/read/brain-hackathon-hacking-brainwaves-to-extend-the-mind
  
Abraham T, Feng J. Evolution of brain imaging instrumentation. Semin Nucl Med. 2011 May;41(3):202-19.
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An article in The Long and Short/New Statesman after a journalist has visited Hackspace:  
  
Baillet S, Mosher JC, Laehy RM. Electromagnetic brain mapping. IEEE Signal Processing Magazine 2001;Nov:14–30.  
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http://thelongandshort.org/issues/season-four/hooking-up-zapping-your-brain.html
  
Bauer H. Slow potential topography. Behav Res Methods Instrum Comput 30: 20–33, 1998.
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http://www.newstatesman.com/lifestyle/2015/07/hacking-brain-can-diy-neuroscience-make-you-happier-and-smarter
  
Bauer H, Korunka C, and Leodolter M. Technical requirements for high quality scalp DC recordings. Electroencephalogr Clin Neurophysiol 72:545–547, 1989.
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Somewhat confused report at CNN Money:
  
Besson JM, Woody CD, Aleonard P, Thompson HK, Albe-Fessard D, and Marshall WH. Correlations of brain DC shifts with changes in cerebral blood flow. Am J Physiol 218: 284–291, 1970.
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http://money.cnn.com/video/technology/2015/12/02/london-brain-hacker.cnnmoney
  
Birbaumer N, Elbert T, Canavan AG, and Rockstroh B. Slow potentials of the cerebral cortex and behavior. Physiol Rev 70: 1–41, 1990.
+
About our Brain Hacking stand at the Lisbon Maker Faire Sept 2015:
  
Chesler M and Kaila K. Modulation of pH by neuronal activity. Trends Neurosci 15: 396–402, 1992.
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http://nerri.eu/eng/news-highlights/nerri-news/hacking-the-brain-at-lisbon-maker-faire.aspx
  
Kaila K and Ransom BR. Concept of pH and its importance in neurobiology. In: pH and Brain Function, edited by K Kaila and BR Ransom. New York: Wiley-Liss, 1998, p. 3–10.
+
We've got a chapter on the near future of accessible neurostimulation in  
  
Kok, A. (1997). Event-Related-Potential (ERP) Reflections of Mental Resources: A Review and Synthesis. . Biological Psychology, 45, 19-56.
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http://www.amazon.co.uk/Anticipating-2025-radical-changes-whether-ebook/dp/B00L2EAUP8
  
Kropotov, J. D. Quantitative EEG, Event-Related Potentials and Neurotherapy. Elsevier, 2009.
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and another two on neurosocial networks and on machine learning in
  
Hari R., Salmelin R. Human cortical oscillations: a neuromagnetic view through the skull // Trends Neurosci. - 1997. – V.20.- P.44-49.  
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http://fob.fastfuturepublishing.com/
  
Erin Treacy Solovey et al.  Using fNIRS Brain Sensing in Realistic HCI Settings: Experiments and Guidelines. UIST’09, October 4–7, 2008, Victoria, BC, Canada.
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with presentation videos available at
  
Hoshi Y. Functional near-infrared spectroscopy: current status and future prospects. J Biomed Opt. 2007 Nov-Dec;12(6):062106
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http://londonfuturists.com/2015/06/22/the-future-of-business/
  
Hoshi, Y. (2009). Near-Infrared Spectroscopy for Studying Higher Cognition Neural Correlates of Thinking (pp. 83-93).
 
  
Thomas Elbert. Slow Cortical Potentials Reflect the Regulation of Cortical Excitability. Slow potential changes in the human brain : [Proceedings of a NATO Advanced Research Workshop on Slow Potential Changes in the Human Brain, held May 13 - 16, 1990 in Il Ciocco, Italy] / ed. by W. C. McCallum et al. New York : Plenum Press, pp. 235-251.
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== Bibliography ==
  
Empson JAC: Human brainwaves: the psychological significance of the electroencephalogram. London, Macmillan; 1986.
+
Some relevant reading for those who want to go hardcore :-)  
 
+
Of course it is far from being complete and badly needs to be updated, oh well...
Fairclough, S. H. (2009). Fundamentals of physiological computing. Interacting with Computers, 21(1-2), 133-145.
 
 
 
Ferrari M, Quaresima V. A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application. Neuroimage. 2012 Mar 28.
 
 
 
Ferrari M, Mottola L, Quaresima V. Principles, Techniques, and Limitations of Near Infrared Spectroscopy. Can J Appl Physiol 2004; 29(4): 463-487.
 
 
 
Gersten A, Heimer D, Raz A. Oxygenation and Blood Volume Periodic Waveforms in the Brain. Hunter College preprint 2006;
 
 
 
Gevins, A., & Smith, M. (2003). Neurophysiological measures of cognitive workload during human-computer interaction. Theoretical Issues in Ergonomics Science, 4, 113-131.
 
 
 
Leanne M. et al. This is Your Brain on Interfaces: Enhancing Usability Testing with Functional Near-Infrared Spectroscopy. CHI 2011, Session: Brain & Bio-sensor Interactions. May 7–12, 2011.
 
 
 
Maria Trinidad Herrera Ezquierroa, Patrizia Cherubinob,  Anton Giulio Maglionec, Alfredo Colosimod, Giovanni Vecchiatoc, Tools and techniques to image functional brain activity. International Journal of Bioelectromagnetism Vol. 14, No. 2, pp. 84 - 95, 2012.
 
 
 
Michel C, He B. EEG Mapping and source imaging. In: Schomer, D., Lopes da Silva, F.H. (Eds.), Niedermeyer's Electroencephalography. Lippincott Williams & Wilkins, Philadelphia. 2011:1179-1202.
 
 
 
Andrea Moreno et al. Neurophysiological, metabolic and cellular compartments that drive neurovascular coupling and neuroimaging signals. Frontiers in Neuroenergetics. March2013. Volume5. Article 3.
 
 
 
Nijholt, A., Tan, D., Allison, B., Milan, J. d. R., & Graimann, B. (2008). Brain-computer interfaces for hci and games. Paper presented at the CHI '08 extended abstracts on Human factors in computing systems, Florence, Italy, 3925-3928.
 
 
 
Serences JT, Saproo S. Computational advances towards linking BOLD and behavior. Neuropsychologia. 2012 Mar;50(4):435-46.
 
 
 
Somjen GG and Tombaugh GC. pH Modulation of neuronal excitability and central nervous system functions. In: pH and Brain Function, edited by K Kaila and BR Ransom. New York: Wiley-Liss, 1998, p. 373–393.
 
 
 
Shafi MM, Westover MB, Fox MD, Pascual-Leone A. Exploration and modulation of brain network interactions with noninvasive brain stimulation in combination with neuroimaging. Eur J Neurosci. 2012 Mar;35(6):805-25.
 
 
 
Sheth, S.A., Nemoto, M., Guiou, M., Walker,M., Pouratian, N., and Toga, A.W. (2004). Linear and nonlinear relationships between neuronal activity, oxygen metabolism, and hemodynamic responses. Neuron 42, 347–355.
 
 
 
M.J. Schroeder, R.E. Barr. Quantitative analysis of the electroencephalogram during cranial electrotherapy stimulation. Clinical Neurophysiology 112 (2001) 2075–2083
 
 
 
William O. Tatum. Handbook of EEG interpretation. 2008. ISBN-13: 978-1-933864-11-2
 
 
 
Tong F, Pratte MS. Decoding patterns of human brain activity. Annu Rev Psychol. 2012 Jan 10;63:483-509.
 
 
 
Tschirgi RD and Taylor JL. Slowly changing bioelectric potentials associated with the blood–brain barrier. Am J Physiol 195: 7–22, 1958.
 
 
 
Juha Voipio, Pekka Tallgren, Erkki Heinonen, Sampsa Vanhatalo, and Kai Kaila. Millivolt-Scale DC Shifts in the Human Scalp EEG: Evidence for a Nonneuronal Generator. J Neurophysiol 89: 2208–2214, 2003.
 
 
 
Wallin BG. Sympathetic nerve activity underlying electrodermal and cardiovascular reactions in man. Psychophysiology 18: 470–476, 1981.
 
 
 
----
 
 
 
 
 
'''* Neurostimulation methods and their effects'''
 
 
 
 
 
J. J. Anders, “The potential of light therapy for central nervous system injury and disease,” Photomed. Laser Surg. 27(3), 379–380 (2009).
 
 
 
Andrews SC, Hoy KE, Enticott PG, Daskalakis ZJ, Fitzgerald PB. Improving working memory: the effect of combining cognitive activity and anodal transcranial direct current stimulation to the left dorsolateral prefrontal cortex. Brain Stim 2011;4(2):84–9.
 
 
 
D. W. BARRETT AND F. GONZALEZ-LIMA. TRANSCRANIAL INFRARED LASER STIMULATION PRODUCES BENEFICIAL COGNITIVE AND EMOTIONAL EFFECTS IN HUMANS. Neuroscience 230 (2013) 13–23
 
 
 
Archy O. de Berker, Marom Bikson and Sven Bestmann. Predicting the behavioral impact of transcranial direct current stimulation: issues and limitations.
 
 
 
Brian A Coffman et al. Enhancement of object detection with transcranial direct current stimulation is associated with increased attention BMC Neuroscience 2012, 13:108 Frontiers in Human Neuroscience.  October 2013 | Volume7 | Article 613
 
 
 
Joaquim P. Brasil-Neto Learning, Memory, and Transcranial Direct Current Stimulation. Front Psychiatry. 2012; 3: 80.
 
 
 
Leila Chaieb, Walter Paulus, and Andrea Antal, Evaluating Aftereffects of Short-Duration Transcranial Random Noise Stimulation on Cortical Excitability, Neural Plasticity, vol. 2011, Article ID 105927, 5 pages, 2011.
 
 
 
Richard P. Chi, Allan W. Snyder. Facilitate Insight by Non-Invasive Brain Stimulation. PLoS ONE. February 2011, Volume 6, Issue 2
 
 
 
H. Chung et al., The nuts and bolts of low-level laser (light) therapy, Ann. Biomed. Eng. 40(2), 516–533 (2012).
 
 
 
Creutzfeldt, O. D., Fromm, G. H., & Kapp, H. (1962). Influence of transcortical DC currents on cortical neuronal activity. Experimental Neurology, 5, 436-452.
 
 
 
Day, B. L. (1999). Galvanic vestibular stimulation: new uses for an old tool. Journal of Physiology, 517, 631.
 
 
 
Dockery, C.A., Hueckel-Weng, R., Birbaumer, N., and Plewnia, C. (2009). Enhancement of planning ability by transcranial direct current stimulation. J. Neurosci. 29, 7271–7277.
 
 
 
Francis JT, Gluckman BJ & Schiff SJ (2003). Sensitivity of neurons to weak electric fields. J Neuroscience 23, 7255–7261.
 
 
 
Fregni, F., P. S. Boggio, et al. (2005). Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Experimental Brain Research 166(1): 23-30.
 
 
 
Brita Fritsch et al. Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning. Neuron. 2010 April 29; 66(2): 198–204.
 
 
 
C Gabriel, S Gabriely and E Corthout. The dielectric properties of biological tissues: I. Literature survey. Phys. Med. Biol. 41 (1996) 2231–2249
 
 
 
Ilic S, Leichliter S, Streeter J, Oron A, DeTaboada L, Oron U: Effects of power densities, continuous and pulse frequencies, and number of sessions of low-level laser therapy on intact rat brain. Photomed Laser Surg 2006, 24:458-466.
 
 
 
Ilmoniemi RJ, Virtanen J, Ruohonen J, Karhu J, Aronen HJ, Naatanen R and Katila T. Neuronal responses to magnetic stimulation reveal cortical reactivity and connectivity. Neuroreport 1997;8:3537-3540.
 
 
 
Grafman, J., & Wassermann, E. (1999). Transcranial magnetic stimulation can measure and modulate learning and memory. Neuropsychologia, 37, 159-167.
 
 
 
Jenrow KA, Zhang X, Renehan WE and Liboff AR. Weak ELF magnetic field effects on hippocampal rhythmic slow activity. Exp Neurol 1998;153:328-334.
 
 
 
Hashmi, J.T., et al., Effect of pulsing in low-level light therapy. Lasers Surg Med, 2010. 42(6): p. 450-66.
 
 
 
K. M. Hebeda et al., “Light propagation in the brain depends on nerve fiber orientation,” Neurosurgery 35(4), 720–722 (1994).
 
 
 
Y. Y. Huang et al., “Biphasic dose response in low level light therapy,” Dose Response 7(4), 358–383 (2009).
 
 
 
Y. Y. Huang et al., “Biphasic dose response in low level light therapy— an update,” Dose Response 9(4), 602–618 (2011).
 
 
 
Cohen Kadosh, R., Levy, N., O’Shea, J., Shea, N., and Savulescu, J. (2012). The neuroethics of non-invasive brain stimulation. Curr. Biol. 22, R108–R111.
 
 
 
Cohen Kadosh, R., The Stimulated Brain: Cognitive Enhancement Using Non-Invasive Brain Stimulation. Academic Press Inc (16 Jun 2014) - '''a must have book!'''
 
 
 
Karim, A. A. (2010). Transcranial cortex stimulation as a novel approach for probing the neurobiology of dreams: Clini­cal and neuroethical implications. International Journal of Dream Research, 3, 15-18.
 
 
 
Karim, A. A., Schneider, M., Lotze, M., Veit, R., Sauseng, P., Braun, C., & Birbaumer, N. (2010). The truth about lying: Inhibition of the anterior prefrontal cortex improves de­ceptive behavior. Cerebral Cortex, 20, 205-213.
 
 
 
Karu TI, Kolyakov SF. Exact action spectra for cellular responses relevant to phototherapy. Photomed Laser Surg 2005;23(4):355 – 61.
 
 
 
A. Kienle, F. K. Forster, and R. Hibst, “Anisotropy of light propagation in biological tissue,” Opt. Lett. 29(22), 2617–2619 (2004).
 
 
 
A. Kienle and R. Hibst, “Light guiding in biological tissue due to scattering,” Phys. Rev. Lett. 97(1), 018104 (2006).
 
 
 
King RL, Brown JR, Newsome WT, Pauly KB. Effective parameters for ultrasound-induced in vivo neurostimulation. Ultrasound in Med. & Biol., Ultrasound Med Biol. 2013 Feb;39(2):312-31.
 
 
 
Randy L. King, Julian R. Brown, Kim Butts Pauly. Localization of Ultrasound-Induced In Vivo Neurostimulation in the Mouse Model. Ultrasound in Medicine and Biology. Volume 40, Issue 7 , Pages 1512-1522, July 2014
 
 
 
Kluger, MD,, Benzi M. and William J. Triggs, MD. Use of Transcranial Magnetic Stimulation to Influence Behavior. Current Neurology and Neuroscience Reports 2007, 7:491–497
 
 
 
Min-Fang Kuo and Michael A. Nitsche. Effects of Transcranial Electrical Stimulation on Cognition. Clin EEG Neurosci 2012 43: 192.
 
 
 
Larson J, Wong D, Lynch G: Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long term potentiation. Brain Res 1986, 368:347-350.
 
 
 
Liebetanz, D., Nitsche, M. A., Tergau, F., & Paulus, W. (2002). Pharmacological approach to the mechanisms of tran­scranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain, 125, 2238-2247.
 
 
 
Teresa Iuculano and Roi Cohen Kadosh. The Mental Cost of Cognitive Enhancement. The Journal of Neuroscience, March 6, 2013 • 33(10):4482– 4486
 
 
 
A.A. Marino, E. Nilson, A.L. Chesson, C. Frilot, Effect of low frequency magnetic fields on brain electrical activity in human subjects, Clin. Neurophysiol. 115 (2004) 1195–1201.
 
 
 
Marshall, L., Mölle, M., Hallschmid, M., & Born, J. (2004). Tran­scranial direct current stimulation during sleep improves declarative memory. Journal of Neuroscience, 24, 9985-9992.
 
 
 
Marshall, L., Helgadóttir, H., Mölle, M., & Born, J. (2006). Boost­ing slow oscillations during sleep potentiates memory. Nature, 444, 610-613.
 
 
 
Marshall, L., et al. Slow oscillation electrical brain stimulation during waking promotes EEG theta activity and memory encoding. PNAS,  September 8, 2009,  vol. 106,  no. 36.
 
 
 
McCarthy, T.J., De Taboada, L., Hildebrandt, P.K., Ziemer, E.L., Richieri, S.P., and Streeter, J. (2010). Long-term safety of single and multiple infrared transcranial laser treatments in Sprague-Dawley rats. Photomed. Laser Surg. 28, 663–667
 
 
 
Michalikova S, Ennaceur A, Rensburg Rv, Chazot P: Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light. Neurobiol Learn Mem 2007, 187:312-326.
 
 
 
Bryce P. Mulligan, Michael A. Persinger. Experimental simulation of the effects of sudden increases in geomagnetic activity upon quantitative measures of human brain activity: Validation of correlational studies. Neuroscience Letters 516 (2012) 54– 56
 
 
 
Naeser, M.A., et al., Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports. Photomed Laser Surg, 2011. 29(5): p. 351-8.
 
 
 
Nitsche M A, Liebetanz D, Antal A, Lang N, Tergau F, Paulus W. Modulation of cortical excitability by weak direct current stimulation – technical, safety and functional aspects. Suppl Clin Neurophysiol 2003;56:255–76.
 
 
 
Nitsche, M. A., Liebetanz, D., Lang, N., Antal, A., Tergau, F. & Paulus, W. (2003). Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clinical Neuro­physiology, 114, 2220-2222.
 
 
 
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[[Brain_hackers/bib/measurements|Accessible measurement methodologies and BCI]]
  
'''* Possible molecular level neurostimulation mechanisms and related works'''
 
 
 
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McFadden JJ. Synchronous firing and its influence on the brain's electromagnetic field: evidence for an electromagnetic theory of consciousness. Journal of Consciousness Studies 2002a;9:23-50.
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McFadden JJ. The Conscious Electromagnetic Information (Cemi) Field Theory: The Hard Problem Made Easy? Journal of Consciousness Studies 2002b;9:45-60.
 
  
McFadden JJ. The CEMI Field Theory. Closing the Loop. Journal of Consciousness Studies, 20, No. 1–2, 2013, pp. 153–68.
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Libet B. A testable field theory of mind-brain interaction. Journal of Consciousness Studies 1994;1:119-126.
 
  
Libet B. Conscious mind as a field [letter; comment]. J Theor Biol 1996;178:223-226.
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Pereria A. The Quantum Mind-Classical Brain Problem. NeuroQuantology 2003; 1: 94-118
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Alfredo Pereira Jr. Astrocyte-Trapped Calcium Ions: the Hypothesis of a Quantum-Like Conscious Protectorate. Quantum Biosystems 2007, 2, 80-92
 
  
Persinger, M. A., Dotta, B. T., Saroka, K. S. & Scott, S. A., Congruence of Energies for Cerebral Photon Emissions, Quantitative EEG Activities and ~5 nT Changes in the Proximal Geomagnetic Field Support Spin-based Hypothesis of Consciousness. Journal of Consciousness Exploration & Research, February 2013, Volume 4, Issue 1, pp. 01-24
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Latest revision as of 14:15, 26 November 2017

This is the page of the Brain Hackers aka the Neurohacking/Neuromodulation London Hackspace Group. We do experiments and play around with kits to measure and alter brain activity in a non-invasive way and develop novel accessible neurostimulation means accompanied by real time measurement and feedback. Some of us are trained neuroscientists or electronics engineers, others are hobbyists. All friendly and interested people are welcome to volunteer and participate in trials, but everything is obviously at your own risk (where such risk may exist).

DIY news:

- the current ICIBCI meeting is https://www.meetup.com/NeuroTechLDN/events/245406475/# The page for the project is https://icibici.github.io/site/ and Git is at https://github.com/icibici/Android-diagnostic-app It works, and if anyone wants a kit to try, improve, and develop apps, please contact Colin Rowat <c.rowat@espero.org.uk>

- There is a first academic review of ICIBCI at http://robertoostenveld.nl/first-steps-with-a-e20-single-channel-eeg-system/

- Starting to use pink noise bands for both brainwave entrainment and covering cyclotron/larmor spectra of relevant ions using weak (a few dozen of microtesla) magnetic fields and modulated HF at 24 MHz. Emulation of global geomagnetic resonators ULF bands is to follow.

- It appears, that brainwave entrainment using weak (up to 30 mT) magnetic fields at 10 Hz only works well if supplemented with transcranial IR light (100 mW) at the same frequency

- Electrophoresis of 20 % solution of Piracetam: subjective effect appears in 10-15 min, while for the traditional Piracetam intake it typically takes 1-2 weeks, and is accompanied by a remarkable elevation of higher beta and gamma activity across the whole brain as measured with Muse


We are now in the process of organizing and starting work on a few specific projects from the Project Ideas. More update on this in the coming weeks.


List of measurement and stimulation kit available by different members of the group:


-EEG -> multiple copies of the 1 channel bipolar (TrueSense Kit) sensor, multiple copies of MindWave Mobile (1 channel) and Muse (4 channels), Emotiv Epoc+ (14 channels), KT88 (16 channels, photic stimulation), AMEA slow potentials mapper (2 channels). We have also made an EEG sensor for an audio jack of any smartphone at IMFcamp hackathon - see above.


-tDCS (transcranial direct current stimulation) -> DIY, via Starstim, via foc.us etc.


-tACS/tPCS (transcranial alternate current stimulation) -> DIY, foc.us, thync, Rhythm-2 2 channel tPCS stimulation device, DrTES (transcranial analgesia device)


-Transcranial laser / decoherent light stimulation within optical permeability window of tissues (roughly between 600 and 1200 nm) -> Matrix LLLT with in-built photometer and external biofeedback block, impulse modulated (0-3 kHz) 890 nm and 635 nm single and matrix array lasers, continuous modulated 810 and 640 nm, all-inclusive large laser/LED combining head, Dune lamp (an array of LEDs at 632,7 and 840 nm, 3 mW)


-High Power TMS (very short pulses up to 1 Tesla, modulation 2-2500 Hz) - TDHP40DEL with 4 coils.


-Weak field TMS (transcranial magnetic stimulation, microtesla range or even lower) -> 64 coil Koren/Murphy/Persinger helmet augmented for placement of more coils, smaller phone tap coils - based hats and setups, large (3m) coil, ELF emmit coil, MIT-MT stimulators (0.1-99 Hz range) with different size coils (induction going up to 30 mT max, 8-shaped configuration up to 10 mT) including coils with centrally positioned high power red, IR and blue LEDs for combined transcranial light/photic and magnetic stimulation, MIT-11 stimulator with coils similar to MIT-MT but different induction and frequency step settings, Almag-02 Version 2 running field (up to 50 mT) pre-programmed multi-coil stimulator, Gefest peripheral feedback 4-coil stimulator (tissues impedance - modulated very low (> 1 Hz) frequency fields up to 10 mT), Biomedis M (with a 3 V jack for coils)


- SHF/THF - Aquaton weak (microwatt range) SHF stimulator (1.001 GHz that can be modulated at 0.1, 8 and 16 Hz) with an external antenna, Orbita weak (microwatt range) THF stimulators (unmodulated, 127 GHz (O2 absorbtion frequency) and 150 GHz (NO absorption frequency)), modulated 53.5 GHz module for MIT (~1 mW, 0-99 Hz range), Yav-1M (42.22 GHz, 10 mW) with signal reflection feedback via it's Gunn diode.


- Ultrasound: MIT-11 stimulator supports 44 kHz 2-5 mkm amplitude ultrasound which can be modulated from 0 to 99.9 Hz with a 0.1 Hz step. MIT-MT emitter, 880 kHz, 1 W/cm2, modulation 0-99 Hz.


-Other -> photopletismographs with vegetative status estimation capability, modulated high voltage "singing arc", scopes, magnetometers, function generators, amps, shielded random number generator etc.

Special thanks to: http://www.medintex.com/ for supplying us with kit to test.

Miscellanea:

Michael Persinger's "God Helmet" effectiveness has been reproduced by an independent group: http://www.scribd.com/doc/267811996/God-Helmet-Replication-Study

Possible step towards CEMI: http://www.sciencedaily.com/releases/2016/01/160114121806.htm

Effects of ~100 nT 2 kHz field on short term memory and attention have been detected: http://onlinelibrary.wiley.com/doi/10.1002/bem.21944/full


Politics:

Some of us actively stand for excluding nootropics, ergotropics and adaptogenes from this Bill together with the rest of http://www.transhumanistparty.org.uk/ - see https://www.newscientist.com/article/2074813-youre-not-hallucinating-mps-really-did-pass-crazy-bad-drug-law/ for more details on the issue.

First they ban enhancing substances, and then go after the devices! Join the campaign if you are not indifferent.


Of course, you are more than welcome to suggest other relevant ideas to test and projects to try. The possibilities are, indeed, "Limitless" (pun intended).


P.S.: folks from Mind Hacking and Biohacking groups are, of course, welcome to join in, but we surely need electronics and coding enthusiasts interested in such matters!


For neuroscience and technical questions and curiosities involving brain hacking, feel free to get in touch with any of the following:

Martin Dinov

Andrew Vladimirov

Dirk Bruere


Some of the popular relevant presentations from Andrew can be found here:

https://wiki.london.hackspace.org.uk/w/index.php?title=File:Cogenhancement_part1.pdf

https://wiki.london.hackspace.org.uk/w/index.php?title=File:Cogenchancement_part2.pdf

https://wiki.london.hackspace.org.uk/w/index.php?title=File:The-future-of-accessible-neurostimulation.pdf

https://wiki.london.hackspace.org.uk/w/index.php?title=File:Self_hacking_via_replay_attacks.pdf

https://wiki.london.hackspace.org.uk/w/images/b/b9/The_rise_of_neurosocial_networks.pdf

Some of us on BBC Radio 4 and on Sky TV:

http://www.bbc.co.uk/radio/player/b050zpwt

http://news.sky.com/story/1522367/brain-hacking-on-rise-could-it-make-you-perkier

Us at the first UK Brain hackathon as team Neurocraft:

http://motherboard.vice.com/read/brain-hackathon-hacking-brainwaves-to-extend-the-mind

An article in The Long and Short/New Statesman after a journalist has visited Hackspace:

http://thelongandshort.org/issues/season-four/hooking-up-zapping-your-brain.html

http://www.newstatesman.com/lifestyle/2015/07/hacking-brain-can-diy-neuroscience-make-you-happier-and-smarter

Somewhat confused report at CNN Money:

http://money.cnn.com/video/technology/2015/12/02/london-brain-hacker.cnnmoney

About our Brain Hacking stand at the Lisbon Maker Faire Sept 2015:

http://nerri.eu/eng/news-highlights/nerri-news/hacking-the-brain-at-lisbon-maker-faire.aspx

We've got a chapter on the near future of accessible neurostimulation in

http://www.amazon.co.uk/Anticipating-2025-radical-changes-whether-ebook/dp/B00L2EAUP8

and another two on neurosocial networks and on machine learning in

http://fob.fastfuturepublishing.com/

with presentation videos available at

http://londonfuturists.com/2015/06/22/the-future-of-business/


Bibliography

Some relevant reading for those who want to go hardcore :-) Of course it is far from being complete and badly needs to be updated, oh well...



Accessible measurement methodologies and BCI


Neurostimulation methods and their effects


Possible molecular level neurostimulation mechanisms and related works


Putative subatomic level mechanisms and related works


Neuronal growth promotion and control via neurostimulation


Neurofeedback


Neuronal plasticity, learning, memory, the "binding factor"


Miscellaneous electromagnetic signaling in the brain


Alternative theories of consciousness and related publications for those interested in such weird stuff