Project:Blood typing
From London Hackspace Wiki
How genes code for your blood group
Blood group is determined by the combination of A and B antigens in your red blood cells. A and B individuals have only those antigens, AB individuals have both, and O individuals have none.
The production of these antigens is determined by the "histo-blood group ABO system transferase" gene (1062 base pairs), part of the ABO gene locus. This gene codes for the expression of a glycosyltransferase enzyme which by acting on another antigen(H), produces A or B antigens. The A and B allelic forms of the gene code for different forms of glycosyltransferase which affect the H antigen in different ways. O alleles code for another protein that doesn't affect the H antigen, meaning no A or B antigens are expressed.